Inhibitors of Neuronal and Inducible Nitric Oxide Synthase Enhance the Protective Effect of Short-Term Adaptation to Hypoxia in Krushinsky-Molodkina Rats

We studied the protective role of nitric oxide (NO) in the adaptation of Krushinsky-Molodkina rats to moderate hypoxia corresponding to 5000 m altitude above sea level. Selective inhibitors of neuronal and inducible NO-synthases (7-nitroindasol and aminoguanidine) have been found to increase significantly the effect of short-term adaptation to hypoxia during the development of stress-induced damage in these rats.