Journal
CHEMNANOMAT
Volume 5, Issue 8, Pages 1036-1043Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cnma.201900035
Keywords
biomolecules; laser patterning; amyloids; plasmonic nanoparticles; label-free detection
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Unique characteristics of SERS including the possibility to reveal the compositional and structural content of trace amounts of biological samples without any pre-treatment, depict this technique as a promising label-free alternative to standard analytical methods. Despite significant advancements, current SERS substrates for biomolecule detection suffer from a number of issues still impeding their routine usage and commercial exploitation, including complex and expensive fabrication procedures and scarce standardization perspectives. Herein a combined bottom up/top down scheme based on flow-through method plus laser patterning is proposed to prepare dot arrays of silver nanowires on a hydrophobic substrate for catching the analyte content from a minute amount of liquid sample and its rapid SERS inspection. As a consequence, a simple spot-on analysis specifically adapted for reliable identification and characterization of molecules of biomedical interest is made possible. Our attempt may represent a concrete chance for progressing SERS toward widespread commercially viable sensing applications including diagnostics at the point-of-need settings and on-site analyses.
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