Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2019.00055
Keywords
IUGR; FGR; bronchopulmonary dysplasia; cardiac; brain injury; necrotizing enterocolitis
Categories
Funding
- National Health and Medical Research Council (NH&MRC) project grant
- Cerebral Palsy Alliance grant
- Royal Australasian College of Physicians Foundation Fellowship
- NH&MRC Research Fellowships
- National Heart Foundation of Australia
- Australian Research Council Future Fellowship
- Victorian Government's Operational Infrastructure Support Program
Ask authors/readers for more resources
Being born small lays the foundation for short-term and long-term implications for life. Intrauterine or fetal growth restriction describes the pregnancy complication of pathological reduced fetal growth, leading to significant perinatal mortality and morbidity, and subsequent long-term deficits. Placental insufficiency is the principal cause of FGR, which in turn underlies a chronic undersupply of oxygen and nutrients to the fetus. The neonatal morbidities associated with FGR depend on the timing of onset of placental dysfunction and growth restriction, its severity, and the gestation at birth of the infant. In this review, we explore the pathophysiological mechanisms involved in the development of major neonatal morbidities in FGR, and their impact on the health of the infant. Fetal cardiovascular adaptation and altered organ development during gestation are principal contributors to postnatal consequences of FGR. Clinical presentation, diagnostic tools and management strategies of neonatal morbidities are presented. We also present information on the current status of targeted therapies. A better understanding of neonatal morbidities associated with FGR will enable early neonatal detection,monitoring and management of potential adverse outcomes in the newborn period and beyond.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available