Journal
CANCER MANAGEMENT AND RESEARCH
Volume 11, Issue -, Pages 1541-1549Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S193174
Keywords
Huaier; cancer; anti-tumor therapy; traditional Chinese medicine; adjuvant
Categories
Funding
- National Natural Science Foundation of China [G302302014, G302302013, G3FW02302013]
Ask authors/readers for more resources
Trametes robiniophila Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the indirect effects on immune cells. In vitro and in vivo experiment showed Huaier directly inhibited tumor cell proliferation, induced tumor cell death, prevented metastasis and interfered with angiogenesis via various signaling pathways. The immunomodulatory effect of Huaier is associated with enhancement of the number and function of CD4(+) T cells and NK cells, regulation of the polarization and function of macrophages, and elevated secretion of immune stimulatory cytokines. In this review, the anti-cancer effects and combined treatments of Huaier with other anti-cancer therapies, and the underlying mechanisms are summarized and discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available