Journal
FRONTIERS IN CHEMISTRY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2019.00053
Keywords
chemical proteomics; bioactive neolignans; molecular docking; drug affinity responsive target stability; nuclear import
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Funding
- MIUR ITALY PRIN 2015 Top-down and Bottom-up approach in the development of new bioactive chemical entities inspired on natural products scaffolds [2015MSCKCE_003]
- Universita degli Studi di Salerno [ORSA151559]
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Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-beta 1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-beta 1 translocation has been evaluated by in vitro assays.
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