Journal
OPTICA
Volume 6, Issue 3, Pages 370-379Publisher
OPTICAL SOC AMER
DOI: 10.1364/OPTICA.6.000370
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Funding
- MRC/EPSRC/BBSRC [MR/K01577X/1]
- H2020 European Research Council (ERC) [695140]
- Wellcome Trust [091911/Z/10/Z, 096144/Z/11/Z, 107457/Z/15/Z, 203285/C/16/Z, 209412/Z/17/Z]
- Wellcome Trust [091911/Z/10/Z, 096144/Z/11/Z] Funding Source: Wellcome Trust
- MRC [MR/K01577X/1] Funding Source: UKRI
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We present IsoSense, a wavefront sensing method that mitigates sample dependency in image-based sensorless adaptive optics applications in microscopy. Our method employs structured illumination to create additional high spatial frequencies in the image through custom illumination patterns. This improves the reliability of image quality metric calculations and enables sensorless wavefront measurement even in samples with sparse spatial frequency content. We demonstrate the feasibility of IsoSense for aberration correction in a deformable-mirror-based structured illumination super-resolution fluorescence microscope. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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