4.6 Review

Peripheral-Central Neuroimmune Crosstalk in Parkinson's Disease: What Do Patients and Animal Models Tell Us?

Related references

Note: Only part of the references are listed.
Article Neurosciences

Post hoc analysis of the Exenatide-PD trial-Factors that predict response

Dilan Athauda et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

The role of LRRK2 in cell signalling

Kirsten Harvey et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Pharmacology & Pharmacy

Non-steroidal anti-inflammatory drugs and risk of Parkinson's disease in the elderly population: a meta-analysis

Tahmina Nasrin Poly et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Review Neurosciences

Genetically engineered animal models of Parkinson's disease: From worm to rodent

Ludivine S. Breger et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

PET imaging of [11C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

Katarina Varnas et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2019)

Article Clinical Neurology

Can the gut be the missing piece in uncovering PD pathogenesis?

Guillaume Chapelet et al.

PARKINSONISM & RELATED DISORDERS (2019)

Article Biochemistry & Molecular Biology

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Seung Pil Yun et al.

NATURE MEDICINE (2018)

Article Neurosciences

Microglial immune checkpoint mechanisms

Aleksandra Deczkowska et al.

NATURE NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

Alexandre Pare et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Neurosciences

What Effects Might Exenatide have on Non-Motor Symptoms in Parkinson's Disease: A Post Hoc Analysis

Dilan Athauda et al.

JOURNAL OF PARKINSONS DISEASE (2018)

Article Immunology

Neuroinflammation: Microglia and T cells Get Ready to Tango

Sjoerd T. T. Schetters et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Clinical Neurology

Tetracycline repurposing in neurodegeneration: focus on Parkinson's disease

Mariza Bortolanza et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Editorial Material Clinical Neurology

Is constipation in Parkinson's disease caused by gut or brain pathology?

Per Borghammer

PARKINSONISM & RELATED DISORDERS (2018)

Review Neurosciences

Microglia Response During Parkinson's Disease: Alpha-Synuclein Intervention

Sara A. Ferreira et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

A monocyte gene expression signature in the early clinical course of Parkinson's disease

Johannes C. M. Schlachetzki et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, Research & Experimental

Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo

Eugene Bok et al.

EXPERIMENTAL NEUROBIOLOGY (2018)

Review Neurosciences

The Gut and Parkinson's Disease: Hype or Hope?

Filip Scheperjans et al.

JOURNAL OF PARKINSONS DISEASE (2018)

Article Clinical Neurology

Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease

Jens B. Schroeder et al.

FRONTIERS IN NEUROLOGY (2018)

Review Neurosciences

Astrocyte-Neuron Networks: A Multilane Highway of Signaling for Homeostatic Brain Function

Sara Mederos et al.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2018)

Review Developmental Biology

Development and maintenance of the brain's immune toolkit: Microglia and non-parenchymal brain macrophages

Jose P. Lopez-Atalaya et al.

DEVELOPMENTAL NEUROBIOLOGY (2018)

Review Immunology

Microglia and macrophages in brain homeostasis and disease

Qingyun Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Clinical Neurology

The meningeal and choroidal infiltration routes for leukocytes in stroke

Corinne Benakis et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2018)

Review Clinical Neurology

Does Parkinson's disease start in the gut?

Arthur Lionnet et al.

ACTA NEUROPATHOLOGICA (2018)

Review Immunology

Myeloid Cells in the Central Nervous System

Jasmin Herz et al.

IMMUNITY (2017)

Article Endocrinology & Metabolism

Structural and physiological neurovascular changes in idiopathic Parkinson's disease and its clinical phenotypes

Sarah Al-Bachari et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Article Neurosciences

Prying into the Prion Hypothesis for Parkinson's Disease

Patrik Brundin et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Neurosciences

High-dimensional, single-cell characterization of the brain's immune compartment

Ben Korin et al.

NATURE NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson's Disease in Rats

Zhijuan Mao et al.

NEUROCHEMICAL RESEARCH (2017)

Review Neurosciences

Microglial phenotypes in Parkinson's disease and animal models of the disease

Valerie Joers et al.

PROGRESS IN NEUROBIOLOGY (2017)

Article Neurosciences

Influence of Estrogen Modulation on Glia Activation in a Murine Model of Parkinson's Disease

Francesca Siani et al.

FRONTIERS IN NEUROSCIENCE (2017)

Review Psychiatry

Brain microglia in psychiatric disorders

Valeria Mondelli et al.

LANCET PSYCHIATRY (2017)

Article Clinical Neurology

Inflammasome activation and innate immunity in Alzheimer's disease

Michael T. Heneka

BRAIN PATHOLOGY (2017)

Review Immunology

Ontogeny and homeostasis of CNS myeloid cells

Marco Prinz et al.

NATURE IMMUNOLOGY (2017)

Article Neurosciences

LRRK2 levels in immune cells are increased in Parkinson'sdisease

D. A. Cook et al.

NPJ PARKINSONS DISEASE (2017)

Article Biochemistry & Molecular Biology

Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease

Goutam Chandra et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Biochemistry & Molecular Biology

How can rAAV--synuclein and the fibril -synuclein models advance our understanding of Parkinson's disease?

Laura A. Volpicelli-Daley et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Neuroinflammation: the devil is in the details

Damon J. DiSabato et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Mitochondrial dysfunction in Parkinson's disease

Anindita Bose et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Clinical Neurology

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

Caroline H. Williams-Gray et al.

MOVEMENT DISORDERS (2016)

Article Clinical Neurology

Cdk5-Dependent Activation of Neuronal Inflammasomes in Parkinson's Disease

Pei Zhang et al.

MOVEMENT DISORDERS (2016)

Article Immunology

Origin, fate and dynamics of macrophages at central nervous system interfaces

Tobias Goldmann et al.

NATURE IMMUNOLOGY (2016)

Review Immunology

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

Keren Zhou et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2016)

Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Biochemistry & Molecular Biology

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

Yiqing Yan et al.

Review Immunology

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

Eric I. Elliott et al.

IMMUNOLOGICAL REVIEWS (2015)

Review Gastroenterology & Hepatology

Role of Inflammasomes in Intestinal Inflammation and Crohn's Disease

Anthony Opipari et al.

INFLAMMATORY BOWEL DISEASES (2015)

Article Endocrinology & Metabolism

Striatal blood-brain barrier permeability in Parkinson's disease

Madison T. Gray et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Editorial Material Neurosciences

Adaptive Immunity in Neurodegenerative and Neuropsychological Disorders

R. Lee Mosley

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2015)

Review Immunology

Control of adaptive immunity by the innate immune system

Akiko Iwasaki et al.

NATURE IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll et al.

NATURE MEDICINE (2015)

Article Clinical Neurology

Increased CSF biomarkers of angiogenesis in Parkinson disease

Shorena Janelidze et al.

NEUROLOGY (2015)

Article Neurosciences

Saxagliptin: A novel antiparkinsonian approach

Noha N. Nassar et al.

NEUROPHARMACOLOGY (2015)

Article Clinical Neurology

Characterization of gastrointestinal disorders in patients with parkinsonian syndromes

Hyeyoung Park et al.

PARKINSONISM & RELATED DISORDERS (2015)

Article Chemistry, Medicinal

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease

Shreesh Ojha et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2015)

Article Neurosciences

Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation

Sonia George et al.

JOURNAL OF PARKINSONS DISEASE (2015)

Article Multidisciplinary Sciences

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Elisa Gomez Perdiguero et al.

NATURE (2015)

Review Neurosciences

Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease

Heather E. Allen Reish et al.

JOURNAL OF PARKINSONS DISEASE (2015)

Article Clinical Neurology

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

Veselin Grozdanov et al.

ACTA NEUROPATHOLOGICA (2014)

Review Endocrinology & Metabolism

Role of CCR2 in inflammatory conditions of the central nervous system

Hannah X. Chu et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Article Clinical Neurology

Cerebral microbleeds in patients with Parkinson's disease

Jee Hyun Ham et al.

JOURNAL OF NEUROLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Detection of Microglial Activation in an Acute Model of Neuroinflammation Using PET and Radiotracers 11C-(R)-PK11195 and 18F-GE-180

Alex M. Dickens et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Review Clinical Neurology

Microglial priming in neurodegenerative disease

V. Hugh Perry et al.

NATURE REVIEWS NEUROLOGY (2014)

Article Cell Biology

Correlation between Serum RANTES Levels and the Severity of Parkinson's Disease

Peng Tang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

Article Multidisciplinary Sciences

Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

Joao P. L. Daher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Neurosciences

Astrocytic modulation of blood brain barrier: perspectives on parkinson's disease

Ricardo Cabezas et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Clinical Neurology

Cognitive Status Correlates with CXCL10/IP-10 Levels in Parkinson's Disease

Natalia Pessoa Rocha et al.

PARKINSONS DISEASE (2014)

Article Medicine, Research & Experimental

Exenatide and the treatment of patients with Parkinson's disease

Iciar Aviles-Olmos et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Immunology

Origin of monocytes and macrophages in a committed progenitor

Jan Hettinger et al.

NATURE IMMUNOLOGY (2013)

Article Neurosciences

The microglial sensome revealed by direct RNA sequencing

Suzanne E. Hickman et al.

NATURE NEUROSCIENCE (2013)

Article Clinical Neurology

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

S. Iannaccone et al.

PARKINSONISM & RELATED DISORDERS (2013)

Review Neurosciences

The Role of Innate and Adaptive Immunity in Parkinson's Disease

George T. Kannarkat et al.

JOURNAL OF PARKINSONS DISEASE (2013)

Article Biochemistry & Molecular Biology

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease

Elisa Greggio

BIOCHEMICAL SOCIETY TRANSACTIONS (2012)

Article Biochemistry & Molecular Biology

Impaired hepatic function and central dopaminergic denervation in a rodent model of Parkinson's disease: A self-perpetuating crosstalk?

Mariapia Vairetti et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Endocrinology & Metabolism

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

David R. Owen et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Clinical Neurology

Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy

Brinda Desai Bradaric et al.

JOURNAL OF NEURAL TRANSMISSION (2012)

Article Neurosciences

CD4+Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson's Disease

Jessica A. Hutter Saunders et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2012)

Article Immunology

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease

Valerio Pisani et al.

JOURNAL OF NEUROINFLAMMATION (2012)

Article Clinical Neurology

Association between Parkinson's disease and the HLA-DRB1 locus

Ismail Ahmed et al.

MOVEMENT DISORDERS (2012)

Review Neurosciences

The path from the choroid plexus to the subventricular zone: go with the flow!

Ana Mendanha Falcao et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2012)

Article Clinical Neurology

Cerebrospinal Fluid Biomarkers for Parkinson Disease Diagnosis and Progression

Min Shi et al.

ANNALS OF NEUROLOGY (2011)

Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

Article Neurosciences

Adhesion molecules as potential targets for neuroprotection in a rodent model of Parkinson's disease

Marie-Therese Armentero et al.

NEUROBIOLOGY OF DISEASE (2011)

Article Endocrinology & Metabolism

MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain

Dario Domenico Lofrumento et al.

NEUROIMMUNOMODULATION (2011)

Article Clinical Neurology

Use of ibuprofen and risk of Parkinson disease

Xiang Gao et al.

NEUROLOGY (2011)

Article Multidisciplinary Sciences

Evidence for More than One Parkinson's Disease-Associated Variant within the HLA Region

Erin M. Hill-Burns et al.

PLOS ONE (2011)

Review Clinical Neurology

Lipopolysaccharide Animal Models for Parkinson's Disease

Mei Liu et al.

PARKINSONS DISEASE (2011)

Article Immunology

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Noel C. Derecki et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Immunology

LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens

Agnes Gardet et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Immunology

Tickets to the brain: Role of CCR2 and CX3CR1 in myeloid cell entry in the CNS

Marco Prinz et al.

JOURNAL OF NEUROIMMUNOLOGY (2010)

Article Clinical Neurology

Anti-inflammatory drugs and risk of Parkinson disease A meta-analysis

Joshua J. Gagne et al.

NEUROLOGY (2010)

Review Multidisciplinary Sciences

Development of Monocytes, Macrophages, and Dendritic Cells

Frederic Geissmann et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

Article Medicine, Research & Experimental

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

Vanessa Brochard et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Article Clinical Neurology

Acute and Chronic 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Administrations Elicit Similar Microglial Activation in the Substantia Nigra of Monkeys

Marianne Vazquez-Claverie et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)

Article Neurosciences

Progressive Dopaminergic Degeneration in the Chronic MPTPp Mouse Model of Parkinson's Disease

Nicoletta Schintu et al.

NEUROTOXICITY RESEARCH (2009)

Review Pharmacology & Pharmacy

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

Francesca Cicchetti et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Review Clinical Neurology

A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results

Karl Kieburtz et al.

CLINICAL NEUROPHARMACOLOGY (2008)

Article Biochemistry & Molecular Biology

Reactive oxygen species up-regulate CD11b in microglia via nitric oxide: Implications for neurodegenerative diseases

Avik Roy et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Review Pharmacology & Pharmacy

The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery

Garima Dutta et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2008)

Article Clinical Neurology

Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA

A. L. Bartels et al.

JOURNAL OF NEURAL TRANSMISSION (2008)

Article Clinical Neurology

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

Shaji Theodore et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Neurosciences

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

Tamy C. Frank-Cannon et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Geriatrics & Gerontology

Synuclein activates microglia in a model of Parkinson's disease

Xiaomin Su et al.

NEUROBIOLOGY OF AGING (2008)

Article Multidisciplinary Sciences

Nitrated α-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

Eric J. Benner et al.

PLOS ONE (2008)

Article Pharmacology & Pharmacy

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK–PD experiments

Paulien G.M. Ravenstijn et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2007)

Article Cell Biology

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease

Ashley D. Reynolds et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2007)

Article Neurosciences

Involvement of interferon-γ in microglial-mediated loss of dopaminergic neurons

Matthew P. Mount et al.

JOURNAL OF NEUROSCIENCE (2007)

Review Immunology

What is immune privilege (not)?

Ian Galea et al.

TRENDS IN IMMUNOLOGY (2007)

Article Biochemistry & Molecular Biology

Up-regulation of microglial CD11b expression by nitric oxide

Avik Roy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Neurosciences

Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys

J Miklossy et al.

EXPERIMENTAL NEUROLOGY (2006)

Letter Medicine, General & Internal

LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs

S Lesage et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Clinical Neurology

Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

HL Chen et al.

ANNALS OF NEUROLOGY (2005)

Article Neurosciences

6-Hydroxydopamine-induced alterations in blood-brain barrier permeability

PM Carvey et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)

Article Neurosciences

ATP mediates rapid microglial response to local brain injury in vivo

D Davalos et al.

NATURE NEUROSCIENCE (2005)

Article Multidisciplinary Sciences

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

A Nimmerjahn et al.

SCIENCE (2005)

Review Biochemistry & Molecular Biology

The choroid plexus in the rise, fall and repair of the brain

DF Emerich et al.

BIOESSAYS (2005)

Article Clinical Neurology

Microglial activation and dopamine terminal loss in early Parkinson's disease

Y Ouchi et al.

ANNALS OF NEUROLOGY (2005)

Article Clinical Neurology

Blood-brain barrier dysfunction in Parkinsonian midbrain in vivo

R Kortekaas et al.

ANNALS OF NEUROLOGY (2005)

Article Clinical Neurology

Changes in vascularization in substantia nigra pars compacta of monkeys rendered parkinsonian

C Barcia et al.

JOURNAL OF NEURAL TRANSMISSION (2005)

Review Pharmacology & Pharmacy

Blood-brain barrier transport of cytokines: A mechanism for neuropathology

WA Banks

CURRENT PHARMACEUTICAL DESIGN (2005)

Article Immunology

RANTES: a versatile and controversial chemokine

V Appay et al.

TRENDS IN IMMUNOLOGY (2001)

Article Neurosciences

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

R Betarbet et al.

NATURE NEUROSCIENCE (2000)