Journal
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
Volume 75, Issue -, Pages 138-150Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2059798318017795
Keywords
protein microcrystallography; automated data collection; ZOO
Funding
- JST/PRESTO
- JSPS KAKENHI [15H06862]
- Platform Project for Supporting Drug Discovery and Life Science Research from Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [15H06862] Funding Source: KAKEN
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Owing to the development of brilliant microfocus beamlines, rapid-readout detectors and sample changers, protein microcrystallography is rapidly becoming a popular technique for accessing structural information from complex biological samples. However, the method is time-consuming and labor-intensive and requires technical expertise to obtain high-resolution protein crystal structures. At SPring-8, an automated data-collection system named ZOO has been developed. This system enables faster data collection, facilitates advanced data-collection and data-processing techniques, and permits the collection of higher quality data. In this paper, the key features of the functionality put in place on the SPring-8 microbeam beamline BL32XU are described and the major advantages of this system are outlined. The ZOO system will be a major driving force in the evolution of the macromolecular crystallography beamlines at SPring-8.
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