Journal
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
Volume 75, Issue -, Pages 239-259Publisher
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S205327331900113X
Keywords
iterative projection algorithms; shape transforms; shape transform phasing; phase retrieval; nanocrystals; serial femtosecond crystallography; X-ray free-electron lasers
Categories
Funding
- NSF STC Award [DBI-1231306]
- NSF Award [DBI-1565180]
- Advanced Scientific Computing Research program
- Basic Energy Sciences program
- Office of Science of the US Department of Energy [DE-AC02-05CH11231]
Ask authors/readers for more resources
Diffraction patterns from small protein crystals illuminated by highly coherent X-rays often contain measurable interference signals between Bragg peaks. This coherent 'shape transform' signal introduces enough additional information to allow the molecular densities to be determined from the diffracted intensities directly, without prior information or resolution restrictions. However, the various correlations amongst molecular occupancies/vacancies at the crystal surface result in a subtle yet critical problem in shape transform phasing whereby the sublattices of symmetry-related molecules exhibit a form of partial coherence amongst lattice sites when an average is taken over many crystal patterns. Here an iterative phase retrieval algorithm is developed which is capable of treating this problem; it is demonstrated on simulated data.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available