Journal
ANIMAL BIOTECHNOLOGY
Volume 27, Issue 2, Pages 104-112Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10495398.2015.1105240
Keywords
Hair follicle cycles; liaoning cashmere goat; microRNA expression; regulatory networks; skin tissue
Funding
- Foundation of Natural Science Project of Liaoning Province, China [2015020758]
- Scientific and Technology Project of Liaoning Province, China [2014036]
- Foundation of Education Department of Liaoning Province, China [L2010507]
- Foundation for University Talents of Liaoning Province of China [LJQ2013070]
- Projects of Tianzhushan Person of Outstanding Ability of Shenyang Agricultural University (Shenyang, Liaoning, China)
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MicroRNAs (miRNAs) are endogenous small noncoding RNA molecules that negatively regulate gene expression. Herein, we investigated a selective number of miRNAs for their expression in skin tissue of Liaoning Cashmere goat during hair follicle cycles, and their intracellular regulatory networks were constructed based on bioinformatics analysis. The relative expression of six miRNAs (mir-103-3p, -15b-5p, 17-5p, -200b, -25-3p, and -30c-5p) at anagen phase is significantly higher than that at catagen and/or telogen phases. In comparison to anagen, the relative expression of seven miRNAs (mir-148a-3p, -199a-3p, -199a-5p, -24-3p, -30a-5p, -30e-5p, and -29a-3p) was revealed to be significantly up-regulated at catagen and/or telogen stages. The network analyses of miRNAs indicated those miRNAs investigated might be directly or indirectly involved in several signaling pathways through their target genes. These results provided a foundation for further insight into the roles of these miRNAs in skin tissue of Liaoning Cashmere goat during hair follicle cycles.
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