Journal
JOURNAL OF BIOLOGICAL ENGINEERING
Volume 13, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13036-018-0138-z
Keywords
Bacterial toxin; Anti-virulence; Cell membrane; Receptor decoys; Antibiotic resistance
Funding
- National Institutes of Health [DE027769, DE025275, DE026962]
- National Science Foundation [1554417]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1554417] Funding Source: National Science Foundation
Ask authors/readers for more resources
Over recent years, the development of new antibiotics has not kept pace with the rate at which bacteria develop resistance to these drugs. For this reason, many research groups have begun to design and study alternative therapeutics, including molecules to specifically inhibit the virulence of pathogenic bacteria. Because many of these pathogenic bacteria release protein toxins, which cause or exacerbate disease, inhibition of the activity of bacterial toxins is a promising anti-virulence strategy. In this review, we describe several approaches to inhibit the initial interactions of bacterial toxins with host cell membrane components. The mechanisms by which toxins interact with the host cell membrane components have been well-studied over the years, leading to the identification of therapeutic targets, which have been exploited in the work described here. We review efforts to inhibit binding to protein receptors and essential membrane lipid components, complex assembly, and pore formation. Although none of these molecules have yet been demonstrated in clinical trials, the in vitro and in vivo results presented here demonstrate their promise as novel alternatives and/or complements to traditional antibiotics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available