Journal
FRONTIERS IN NEUROSCIENCE
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2019.00030
Keywords
mitochondrial dysfunction; neural injury; mitochondria; neurodegeneration; neurological disorders
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Funding
- National Natural Science Foundation of China [81671111, 81870897, 81601111]
- Suzhou Clinical Research Center of Neurological Disease [Szzx201503]
- Jiangsu Provincial Special Program of Medical Science [BK20181436]
- Jiangsu Higher Education Institutions
- Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases [BM2013003]
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Mitochondria are the double membrane organelles providing most of the energy for cells. In addition, mitochondria also play essential roles in various cellular biological processes such as calcium signaling, apoptosis, ROS generation, cell growth, and cell cycle. Mitochondrial dysfunction is observed in various neurological disorders which harbor acute and chronic neural injury such as neurodegenerative diseases and ischemia, hypoxia-induced brain injury. In this review, we describe how mitochondrial dysfunction contributes to the pathogenesis of neurological disorders which manifest chronic or acute neural injury.
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