Journal
CATALYSTS
Volume 9, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/catal9030221
Keywords
2-oxoglutarate-dependent oxygenases; industrial biocatalysis; hydroxylation; alpha-ketoglutarate; amino acid modification; antibiotic synthesis
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Funding
- Swiss State Secretariat for Education, Research and Innovation
- Innosuisse-Swiss Innovation Agency [28385.1 PFLS-LS]
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C-H functionalization is a chemically challenging but highly desirable transformation. 2-oxoglutarate-dependent oxygenases (2OGXs) are remarkably versatile biocatalysts for the activation of C-H bonds. In nature, they have been shown to accept both small and large molecules carrying out a plethora of reactions, including hydroxylations, demethylations, ring formations, rearrangements, desaturations, and halogenations, making them promising candidates for industrial manufacture. In this review, we describe the current status of 2OGX use in biocatalytic applications concentrating on 2OGX-catalyzed oxyfunctionalization of amino acids and synthesis of antibiotics. Looking forward, continued bioinformatic sourcing will help identify additional, practical useful members of this intriguing enzyme family, while enzyme engineering will pave the way to enhance 2OGX reactivity for non-native substrates.
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