Journal
CATALYSTS
Volume 9, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/catal9030208
Keywords
oxidation; whole cells; immobilization; biocatalysis; flow reactor; reactor design
Categories
Funding
- Cariplo Foundation [2014-0568]
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Enantiomerically enriched 2-hydroxymethylalkanoic acids were prepared by oxidative desymmetrisation of achiral 1,3-diols using immobilized cells of Acetobacter aceti in water at 28 degrees C. The biotransformations were first performed in batch mode with cells immobilized in dry alginate, furnishing the desired products with high molar conversion and reaction times ranging from 2 to 6 h. The biocatalytic process was intensified using a multiphasic flow reactor, where a segmented gas-liquid flow regime was applied for achieving an efficient O-2-liquid transfer; the continuous flow systems allowed for high yields and high biocatalyst productivity.
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