Journal
MEDICAL SCIENCE MONITOR
Volume 25, Issue -, Pages 1828-1837Publisher
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.912867
Keywords
Acute Lung Injury; Autophagy; HMGB1 Protein
Categories
Funding
- National Natural Science Foundation of China [81100054]
- Hunan Natural Science Foundation [2018JJ2255]
- Hunan Natural Science Foundation Joint Project of Science and Health [2018JJ6052]
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Acute lung injury (ALI) is a life-threatening clinical syndrome in critically ill patients. The identification of novel biological markers for the early diagnosis of ALI and the development of more effective treatments are topics of current research. High mobility group box-1 protein (HMGB1) is a late inflammatory mediator associated with sepsis, malignancy, and immune disease. Levels of HMGB1 may reflect the severity of inflammation and tissue damage, indicating a potential role for HMGB1 as a prognostic biomarker in ALI, and a potential target for blocking inflammatory pathways. Several studies have shown that HMGB1 regulates autophagy. Autophagy, or type II programmed cell death, is an essential biological process that maintains cellular homeostasis. Studies have shown that HMGB1 and autophagy are involved in the pathogenesis of many lung diseases including ALI but the specific mechanisms underlying this association remain to be determined. This review aims to provide an update on the current status of the role of HMBG1 and autophagy in ALI.
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