Journal
JOURNAL OF NANOBIOTECHNOLOGY
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12951-019-0473-3
Keywords
Stimuli-responsive; Sequential drug release; Synergistic effect; Dual drug; Combination therapy; NIR photothermal effect
Funding
- National Natural Science Foundation of China [81402854]
- National Key Specialty Construction Project of Clinical Pharmacy [30305030698]
- President Foundation of Nanfang Hospital, Southern Medical University [2014033]
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BackgroundThe combination of multiple chemotherapeutics has been used in the clinic for enhanced cancer chemotherapy, however, frequent relapse, chemo-resistance and side effects remains therapeutic hurdles. Thus, the development of co-delivery system with enhanced targeting and synergistic different modal treatments has been proposed as promising strategies for intensive improvement of the therapeutic outcomes.ResultsWe fabricated a nanocarrier based on gold nanorods (Au NRs), cRGD peptide-modified and multi-stimuli-responsive paclitaxel (PTX) and curcumin (CUR) release for synergistic anticancer effect and chemo-photothermal therapy (PTX/CUR/Au NRs@cRGD). The specific banding of cRGD to v3 integrin receptor on the tumor cell surfaces facilitated the endocytosis of PTX/CUR/Au NRs@cRGD, and the near-infrared ray (NIR) further enhanced the drug release and chemotherapeutical efficiency. Compared to single drug, single model treatment or undecorated-PTX/CUR/Au NRs, the PTX/CUR/Au NRs@cRGD with a mild NIR showed significantly enhanced apoptosis and S phase arrest in three cancer cell lines in vitro, and improved drug accumulation in tumor sites as well as tumor growth inhibition in vivo.ConclusionsThe tumor targeted chemo-photothermal therapy with the synergistic effect of dual drugs provided a versatile strategy for precise cancer therapy.
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