Journal
EXPERIMENTAL BRAIN RESEARCH
Volume 237, Issue 6, Pages 1479-1491Publisher
SPRINGER
DOI: 10.1007/s00221-019-05511-4
Keywords
Auditory nerve model; Computational modeling; Efferent; MOC; IC
Categories
Funding
- University Malaya Research Grants (UMRG) from the Institute of Research Management & Monitoring (IPPP) University of Malaya [RP016B-13AET, RP006-13ICT]
- Research University Grant (RU Faculty) from the Faculty of Engineering, University of Malaya [GPF039A-2018]
Ask authors/readers for more resources
Various studies on medial olivocochlear (MOC) efferents have implicated it in multiple roles in the auditory system (e.g., dynamic range adaptation, masking reduction, and selective attention). This study presents a systematic simulation of inferior colliculus (IC) responses with and without electrical stimulation of the MOC. Phenomenological models of the responses of auditory nerve (AN) fibers and IC neurons were used to this end. The simulated responses were highly consistent with physiological data (replicated 3 of the 4 known rate-level responses all MOC effectsshifts, high stimulus level reduction and enhancement). Complex MOC efferent effects which were previously thought to require integration from different characteristic frequency (CF) neurons were simulated using the same frequency inhibition excitation circuitry. MOC-induced enhancing effects were found only in neurons with a CF range from 750Hz to 2kHz. This limited effect is indicative of the role of MOC activation on the AN responses at the stimulus offset.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available