Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 47, Issue 1, Pages 278-289Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2018.1553783
Keywords
MiR-30a-5p; prostate cancer; PCLAF; proliferation
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Funding
- Military Medical Scientific Youth Cultivation Project [15QNP205]
- Outstanding Youth Funds of Fuzhou General Hospital [2015Q04, 2017Q05]
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MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.
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