Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 30, Pages 8696-8700Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602224
Keywords
amination; arenes; C-H activation; reaction mechanisms; rhodium
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Funding
- Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- NSFC [21525208, 21472186]
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Previous direct C-H nitrogenation suffered from simple amidation/amination with limited atom-economy and is mostly limited to C(sp(2))-H substrates. In this work, anthranil was designed as a novel bifunctional aminating reagent for both C(sp(2)) H and C(sp(3)) H bonds under rhodium(III) catalysis, thus affording a nucleophilic aniline tethered to an electrophilic carbonyl. A tridendate rhodium(III) complex has been isolated as the resting state of the catalyst, and DFT studies established the intermediacy of a nitrene species.
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