4.5 Review

Splicing and cancer: Challenges and opportunities

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing

Michael A. Gordon et al.

MOLECULAR CARCINOGENESIS (2019)

Article Cell Biology

Structure of the human activated spliceosome in three conformational states

Xiaofeng Zhang et al.

CELL RESEARCH (2018)

Review Cell Biology

The role of alternative splicing in cancer drug resistance

Zahava Siegfried et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)

Article Medicine, Research & Experimental

Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability

Kenichi Iwai et al.

EMBO MOLECULAR MEDICINE (2018)

Article Biochemistry & Molecular Biology

MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation

Jun Huang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

Constantin Cretu et al.

MOLECULAR CELL (2018)

Article Genetics & Heredity

The long tail of oncogenic drivers in prostate cancer

Joshua Armenia et al.

NATURE GENETICS (2018)

Article Biochemistry & Molecular Biology

Global profiling of hnRNP A2/B1-RNA binding on chromatin highlights LncRNA interactions

Eric D. Nguyen et al.

RNA BIOLOGY (2018)

Article Cell Biology

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

Reyka G. Jayasinghe et al.

CELL REPORTS (2018)

Article Multidisciplinary Sciences

Prespliceosome structure provides insights into spliceosome assembly and regulation

Clemens Plaschka et al.

NATURE (2018)

Review Oncology

Alternative splicing in prostate cancer

Alec Paschalis et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT

Samuel E. Harvey et al.

Article Multidisciplinary Sciences

Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

Simon Braun et al.

NATURE COMMUNICATIONS (2018)

Article Genetics & Heredity

Long noncoding RNA MALAT1 suppresses breast cancer metastasis

Jongchan Kim et al.

NATURE GENETICS (2018)

Article Oncology

Molecular Pathways: Understanding and Targeting Mutant Spliceosomal Proteins

Akihide Yoshimi et al.

CLINICAL CANCER RESEARCH (2017)

Review Cell Biology

Modulating splicing with small molecular inhibitors of the spliceosome

Kerstin A. Effenberger et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2017)

Article Multidisciplinary Sciences

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

Karl Bertram et al.

NATURE (2017)

Article Cell Biology

The Functional Impact of Alternative Splicing in Cancer

Hector Climente-Gonzalez et al.

CELL REPORTS (2017)

Article Biochemistry & Molecular Biology

An Atomic Structure of the Human Spliceosome

Xiaofeng Zhang et al.

Article Biochemistry & Molecular Biology

Conformational dynamics of stem II of the U2 snRNA

Margaret L. Rodgers et al.

Review Biochemistry & Molecular Biology

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability

Jeremy E. Wilusz

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)

Review Genetics & Heredity

The hnRNP family: insights into their role in health and disease

Thomas Geuens et al.

HUMAN GENETICS (2016)

Review Biochemistry & Molecular Biology

Therapeutic targeting of splicing in cancer

Stanley Chun-Wei Lee et al.

NATURE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

Kerstin A. Effenberger et al.

Review Oncology

RNA splicing factors as oncoproteins and tumour suppressors

Heidi Dvinge et al.

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

SRSF1-Regulated Alternative Splicing in Breast Cancer

Olga Anczukow et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

Tiffany Y. -T. Hsu et al.

NATURE (2015)

Article Genetics & Heredity

Intron retention is a widespread mechanism of tumor-suppressor inactivation

Hyunchul Jung- et al.

NATURE GENETICS (2015)

Article Oncology

RON alternative splicing regulation in primary ovarian cancer

Sebastian Mayer et al.

ONCOLOGY REPORTS (2015)

Article Multidisciplinary Sciences

Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome

Vikas Madan et al.

NATURE COMMUNICATIONS (2015)

Article Biochemical Research Methods

Transcriptome Sequencing Reveals Potential Mechanism of Cryptic 3′ Splice Site Selection in SF3B1-mutated Cancers

Christopher DeBoever et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

U2AF1 mutations alter splice site recognition in hematological malignancies

Janine O. Ilagan et al.

GENOME RESEARCH (2015)

Article Oncology

SF3B1 mutations constitute a novel therapeutic target in breast cancer

Sarah L. Maguire et al.

JOURNAL OF PATHOLOGY (2015)

Article Oncology

PRPF8 defects cause missplicing in myeloid malignancies

A. Kurtovic-Kozaric et al.

LEUKEMIA (2015)

Review Biochemistry & Molecular Biology

Alternative splicing in cancer: implications for biology and therapy

J. Chen et al.

ONCOGENE (2015)

Review Biochemistry & Molecular Biology

Long non-coding RNA HOTAIR in carcinogenesis and metastasis

Jinsong Zhang et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2014)

Article Biochemistry & Molecular Biology

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

Fran Supek et al.

Article Otorhinolaryngology

Prognostic significance of bone invasion for oral cavity squamous cell carcinoma considered T1/T2 by American Joint Committee on Cancer size criteria

David Fried et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2014)

Article Biochemistry & Molecular Biology

Identification of Small Molecule Inhibitors of Pre-mRNA Splicing

Andrea Pawellek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Review Genetics & Heredity

Context-dependent control of alternative splicing by RNA-binding proteins

Xiang-Dong Fu et al.

NATURE REVIEWS GENETICS (2014)

Review Cell Biology

A day in the life of the spliceosome

A. Gregory Matera et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Structural requirement of Ntc77 for spliceosome activation and first catalytic step

Hsin-Chou Chen et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation

Ahmed Moursy et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

Sudemycin E influences alternative splicing and changes chromatin modifications

Paolo Convertini et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Biochemistry & Molecular Biology

Hallmarks of alternative splicing in cancer

S. Oltean et al.

ONCOGENE (2014)

Article Genetics & Heredity

The RNA-Binding Protein QKI Suppresses Cancer-Associated Aberrant Splicing

Feng-Yang Zong et al.

PLOS GENETICS (2014)

Article Biotechnology & Applied Microbiology

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp No. 2663

Xiangyang Liu et al.

JOURNAL OF ANTIBIOTICS (2013)

Article Biochemistry & Molecular Biology

RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues

Julian P. Venables et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

Elias G. Bechara et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

Competition between Pre-mRNAs for the Splicing Machinery Drives Global Regulation of Splicing

Elizabeth M. Munding et al.

MOLECULAR CELL (2013)

Article Biochemistry & Molecular Biology

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

Shatakshi Pandit et al.

MOLECULAR CELL (2013)

Article Genetics & Heredity

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

J. William Harbour et al.

NATURE GENETICS (2013)

Review Cell Biology

Alternative splicing: a pivotal step between eukaryotic transcription and translation

Alberto R. Kornblihtt et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

A complex network of factors with overlapping affinities represses splicing through intronic elements

Yang Wang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Review Biochemistry & Molecular Biology

On the classification of long non-coding RNAs

Lina Ma et al.

RNA BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

Marcin Imielinski et al.

Article Biochemistry & Molecular Biology

Snail Represses the Splicing Regulator Epithelial Splicing Regulatory Protein 1 to Promote Epithelial-Mesenchymal Transition

Lauren M. Reinke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

The landscape of cancer genes and mutational processes in breast cancer

Philip J. Stephens et al.

NATURE (2012)

Article Multidisciplinary Sciences

Whole-genome analysis informs breast cancer response to aromatase inhibition

Matthew J. Ellis et al.

NATURE (2012)

Article Multidisciplinary Sciences

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Andrew V. Biankin et al.

NATURE (2012)

Article Genetics & Heredity

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

Timothy A. Graubert et al.

NATURE GENETICS (2012)

Review Biotechnology & Applied Microbiology

The spliceosome as a target of novel antitumour drugs

Sophie Bonnal et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Biochemistry & Molecular Biology

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

Olga Anczukow et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules

Yang Wang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Oncology

A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma

Karin Wadt et al.

PIGMENT CELL & MELANOMA RESEARCH (2012)

Article Multidisciplinary Sciences

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells

Hannah L. Gautrey et al.

PLOS ONE (2012)

Review Biochemistry & Molecular Biology

Hallmarks of cancer: of all cancer cells, all the time?

Sebastien L. Floor et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Article Oncology

Cancer stem cells: an evolving concept

Long V. Nguyen et al.

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

Liying Fan et al.

ACS CHEMICAL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Chemistry, Multidisciplinary

Structural Requirements for the Antiproliferative Activity of Pre-mRNA Splicing Inhibitor FR901464

Sami Osman et al.

CHEMISTRY-A EUROPEAN JOURNAL (2011)

Article Biochemistry & Molecular Biology

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

Clare V. LeFave et al.

EMBO JOURNAL (2011)

Review Biochemistry & Molecular Biology

Serine-arginine protein kinases: a small protein kinase family with a large cellular presence

Thomas Giannakouros et al.

FEBS JOURNAL (2011)

Article Biochemistry & Molecular Biology

SR Proteins Induce Alternative Exon Skipping through Their Activities on the Flanking Constitutive Exons

Joonhee Han et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikos I. Poulikakos et al.

NATURE (2011)

Article Multidisciplinary Sciences

Frequent pathway mutations of splicing machinery in myelodysplasia

Kenichi Yoshida et al.

NATURE (2011)

Article Medicine, General & Internal

Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts

E. Papaemmanuil et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Medicine, General & Internal

SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

Lili Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Cell Biology

Spliceosome Structure and Function

Cindy L. Will et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Biochemistry & Molecular Biology

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

Michael J. Moore et al.

Article Oncology

RBM5 as a Putative Tumor Suppressor Gene for Lung Cancer

Leslie C. Sutherland et al.

JOURNAL OF THORACIC ONCOLOGY (2010)

Article Biochemistry & Molecular Biology

Invariant U2 snRNA Nucleotides Form a Stem Loop to Recognize the Intron Early in Splicing

Rhonda Perriman et al.

MOLECULAR CELL (2010)

Article Genetics & Heredity

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

Thomas Ernst et al.

NATURE GENETICS (2010)

Article Biochemistry & Molecular Biology

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

Gabriel A. Roybal et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Medicine, General & Internal

A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma

Jeran K. Stratford et al.

PLOS MEDICINE (2010)

Review Biochemistry & Molecular Biology

The SR protein family of splicing factors: master regulators of gene expression

Jennifer C. Long et al.

BIOCHEMICAL JOURNAL (2009)

Article Biochemistry & Molecular Biology

Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts

Jeremy R. Sanford et al.

GENOME RESEARCH (2009)

Article Chemistry, Medicinal

Synthetic mRNA Splicing Modulator Compounds with in Vivo Antitumor Activity

Chandraiah Lagisetti et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Cancer-associated regulation of alternative splicing

Julian P. Venables et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Review Oncology

Apoptosis and cancer: the genesis of a research field

Thomas G. Cotter

NATURE REVIEWS CANCER (2009)

Article Genetics & Heredity

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in Transgenic mice

Yimin Hua et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2008)

Article Biochemistry & Molecular Biology

The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1

Gracjan Michlewski et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation

Ran Brosh et al.

MOLECULAR SYSTEMS BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome

Shalini Sharma et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5

Kazuo Fushimi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Yoshihiko Kotake et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Daisuke Kaida et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

Rotem Karni et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

Article Multidisciplinary Sciences

An RNA map predicting Nova-dependent splicing regulation

Jernej Ule et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition

Amy E. House et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Review Peripheral Vascular Disease

Angiogenesis in cancer

Naoyo Nishida et al.

VASCULAR HEALTH AND RISK MANAGEMENT (2006)

Review Biochemistry & Molecular Biology

RB and cell cycle progression

C. Giacinti et al.

ONCOGENE (2006)

Article Biochemistry & Molecular Biology

Intronic binding sites for hnRNP A/B and hnRNP F/H proteins stimulate pre-mRNA splicing

R Martinez-Contreras et al.

PLOS BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

C Ghigna et al.

MOLECULAR CELL (2005)

Article Biochemistry & Molecular Biology

Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals

JG Underwood et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Identification and characterization of a novel gene Saf transcribed from the opposite strand of Fas

MD Yan et al.

HUMAN MOLECULAR GENETICS (2005)

Article Biochemistry & Molecular Biology

Systematic identification and analysis of exonic splicing silencers

ZF Wang et al.

Article Multidisciplinary Sciences

Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping

A Goyenvalle et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

Identification of human brain tumour initiating cells

SK Singh et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

Manipulation of alternative splicing by a newly developed inhibitor of Clks

M Muraki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

The Prp19p-associated complex in spliceosome activation

SP Chan et al.

SCIENCE (2003)

Review Biochemistry & Molecular Biology

Pre-mRNA splicing: Awash in a sea of proteins

MS Jurica et al.

MOLECULAR CELL (2003)

Article Biochemistry & Molecular Biology

A novel splicing regulator shares a nuclear import pathway with SR proteins

MC Lai et al.

EMBO JOURNAL (2003)

Article Multidisciplinary Sciences

Proliferation, cell cycle and apoptosis in cancer

GI Evan et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Modification of alternative splicing of Bcl-x Pre-mRNA in prostate and breast cancer cells - Analysis of apoptosis and cell death

DR Mercatante et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

The Rb/E2F pathway and cancer

JR Nevins

HUMAN MOLECULAR GENETICS (2001)

Review Multidisciplinary Sciences

Initial sequencing and analysis of the human genome

ES Lander et al.

NATURE (2001)