Journal
WILEY INTERDISCIPLINARY REVIEWS-RNA
Volume 10, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/wrna.1526
Keywords
alternative polyadenylation; brain; CPSF; CstF; flowering control; immune system; polyadenylation; spermatogenesis; testis
Categories
Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD037109]
Ask authors/readers for more resources
Alternative polyadenylation (APA) is how genes choose different sites for 3 ' end formation for mRNAs during transcription. APA often occurs in a tissue- or developmental stage-specific manner that can significantly affect gene activity by changing the protein product generated, the stability of the transcript, its localization within the cell, or its translatability. Despite the important regulatory effects that APA has on tissue-specific gene expression, only a few examples have been characterized mechanistically. In this 2018 update to our 2010 review, we examine mechanisms for the control of APA and update our understanding of the older mechanisms since 2010. We once postulated the existence of tissue-specific factors in APA. However, while a few tissue-specific polyadenylation factors are known, the emerging conclusion is that the majority of APA is accomplished by altering levels of core polyadenylation proteins. Examples of those core proteins include CSTF2, CPSF1, and subunits of mammalian cleavage factor I. But despite support for these mechanisms, no one has yet documented any of these proteins changing in either a tissue-specific or developmental manner. Given the profound effect that APA can have on gene expression and human health, improved understanding of tissue-specific APA could lead to numerous advances in gene activity control. This article is categorized under: RNA Processing > 3 ' End Processing RNA in Disease and Development > RNA in Development
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available