Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 37, Pages 11287-11291Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201605193
Keywords
C-H activation; C-heteroatom coupling; cobalt; cross-coupling; thiolation
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A cobalt-catalyzed dehydrogenative cross-coupling of thiols and indoles is reported. Using a cooperative reaction system, a new mode of action for the cobalt-catalyzed C-heteroatom bond formation was found. The directed C-H activation catalysis overrides an undirected thiolation of indole in the 3-position that occurs in the absence of cobalt. Mechanistic studies indicate a sequence of C-H activation, thiolate transfer, and reductive elimination.
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