Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 34, Pages 9993-9996Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604892
Keywords
cyclization; fluorescence; fluorescent probes; hydrogen polysulfides; sulfides
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Funding
- NIH [R01HL116571]
- Grants-in-Aid for Scientific Research [16H00823, 16H05099] Funding Source: KAKEN
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Hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n>1) are endogenous regulators of many physiological processes. In order to better understand the symbiotic relationship and cellular cross-talk between H2S and H2Sn, it is highly desirable to develop single fluorescent probes which enable dual-channel discrimination between H2S and H2Sn. Herein, we report the rational design, synthesis, and evaluation of the first dual-detection fluorescent probe DDP-1 that can visualize H2S and H2Sn with different fluorescence signals. The probe showed high selectivity and sensitivity to H2S and H2Sn in aqueous media and in cells.
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