Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 42, Pages 13023-13027Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201605992
Keywords
imprinting; molecular recognition; polymers; proteins; sensors
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Funding
- JSPS KAKENHI Grant [24651261, 15K14943]
- Japan Science and Technology Agency, JST [MP28116808085, MP28116808112]
- Grants-in-Aid for Scientific Research [24651261, 15K14943] Funding Source: KAKEN
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Inspired by biosystems, a process is proposed for preparing next-generation artificial polymer receptors with molecular recognition abilities capable of programmable site-directed modification following construction of nanocavities to provide multi-functionality. The proposed strategy involves strictly regulated multi-step chemical modifications: 1) fabrication of scaffolds by molecular imprinting for use as molecular recognition fields possessing reactive sites for further modifications at pre-determined positions, and 2) conjugation of appropriate functional groups with the reactive sites by post-imprinting modifications to develop programmed functionalizations designed prior to polymerization, allowing independent introduction of multiple functional groups. The proposed strategy holds promise as a reliable, affordable, and versatile approach, facilitating the emergence of polymer-based artificial antibodies bearing desirable functions that are beyond those of natural antibodies.
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