Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 18, Pages 5477-5482Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510748
Keywords
cancer cells; glutathione; MnO2 nanosheets; photodynamic therapy; singlet oxygen
Categories
Funding
- National Key Scientific Program of China [2011CB911000]
- National Key Basic Research Program of China [2013CB932702]
- NSFC [21325520, 21327009, 21405041, J1210040, 21177036]
- Foundation for Innovative Research Groups of NSFC [21521063]
- National Instrumentation Program [2011YQ030124]
- National Institutes of Health [GM079359, GM111386, CA133086]
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Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species to kill cancer cells. However, a high concentration of glutathione (GSH) is present in cancer cells and can consume reactive oxygen species. To address this problem, we report the development of a photosensitizer-MnO2 nanosystem for highly efficient PDT. In our design, MnO2 nanosheets adsorb photosensitizer chlorin e6 (Ce6), protect it from self-destruction upon light irradiation, and efficiently deliver it into cells. The nanosystem also inhibits extracellular singlet oxygen generation by Ce6, leading to fewer side effects. Once endocytosed, the MnO2 nanosheets are reduced by intracellular GSH. As a result, the nanosystem is disintegrated, simultaneously releasing Ce6 and decreasing the level of GSH for highly efficient PDT. Moreover, fluorescence recovery, accompanied by the dissolution of MnO2 nanosheets, can provide a fluorescence signal for monitoring the efficacy of delivery.
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