Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 34, Pages 9947-9951Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604130
Keywords
cell death; hypoxia; iridium; photodynamic therapy; singlet oxygen
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Funding
- National Natural Science Foundation of China [51473078, 61136003]
- National Program for Support of Top-Notch Young Professionals, Scientific and Technological Innovation Teams of Colleges and Universities in Jiangsu Province [TJ215006]
- Natural Science Foundation of Jiangsu Province of China [BK20130038, BM2012010]
- Synergetic Innovation Center for Organic Electronics and Information Displays
- Priority Academic Program Development of Jiangsu Higher Education Institutions [YX03001]
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Organelle-targeted photosensitizers have been reported to be effective photodynamic therapy (PDT) agents. In this work, we designed and synthesized two iridium(III) complexes that specifically stain the mitochondria and lysosomes of living cells, respectively. Both complexes exhibited long-lived phosphorescence, which is sensitive to oxygen quenching. The photocytotoxicity of the complexes was evaluated under normoxic and hypoxic conditions. The results showed that HeLa cells treated with the mitochondria-targeted complex maintained a slower respiration rate, leading to a higher intracellular oxygen level under hypoxia. As a result, this complex exhibited an improved PDT effect compared to the lysosome-targeted complex, especially under hypoxia conditions, suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.
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