Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 35, Pages 10512-10517Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604658
Keywords
allosteric control; coordination chemistry; molecular switches; nanomechanical motion; sequential catalysis
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Funding
- DAAD (Deutscher Akademischer Austauschdienst)
- DFG Deutsche Forschungsgemeinschaft [Schm-647/19-1]
- Universitat Siegen
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The nanomechanical switch 1 with its three orthogonal binding motifs-the zinc(II) porphyrin, azaterpyridine, and shielded phenanthroline binding station-is quantitatively and reversibly toggled back and forth between four different switching states by means of addition and removal of appropriate metal-ion inputs. Two of the four switching stages are able to initiate catalytic transformations (ON1, ON2), while the two others shut down any reaction (OFF1, OFF2). Thus, in a cyclic four-state switching process the sequential transformation A + B + C -> AB + C -> ABC can be controlled, which proceeds stepwise along the switching states OFF1! ON1 (click reaction: A + B -> AB)-> OFF2 -> ON2 (Michael addition: AB + C -> ABC) -> OFF1. Two consecutive cycles of the sequential catalysis were realized without loss in activity in a reaction system with eleven different components.
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