Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 37, Pages 10978-10999Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601931
Keywords
light delivery; light therapy; photopharmacology; photoswitching; smart drugs
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Funding
- European Research Council [227897] Funding Source: Medline
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The field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment. By using small molecules, photopharmacology provides a viable alternative to optogenetics. We present here a critical overview of the different pharmacological targets in various organs and a survey of organ systems in the human body that can be addressed in a non-invasive manner. We discuss the prospects for the selective delivery of light to these organs and the specific requirements for light-activatable drugs. We also aim to illustrate the druggability of medicinal targets with recent findings and emphasize where conceptually new approaches have to be explored to provide photopharmacology with future opportunities to bring smart molecular design ultimately to the realm of clinical use.
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