Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 4, Pages 987-991Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609031
Keywords
coordination polymers; nanocarriers; nanoribbons; oligonucleotides
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Funding
- Spanish Ministerio de Economia y Competitividad [MAT2016-75883-C2-2-P, MAT2016-77608-C3-1-P, MAT2013-46502-C2-1P/2P, MAT2013-46753-C2-1-P, MAT2010-20843-C02-01, SAF2014-56763-R]
- Asociacion Espanola Contra el Cancer, Generalitat Valenciana [PrometeoII/2014/076, ISIC]
- EU [FP6-029192]
- Chilean Ministry of Education CONICYT
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The direct reaction between copper nitrate, thymine-1-acetic acid, and 4,4'-bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length > 1 mu m; width ca. 150-185 nm; diameter ca. 15-60 nm) of a coordination polymer. The polymer displays a thymine-based structure freely available for supra-molecular interactions. These nanostructures show significant selective interaction with single-stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines-despite the copper(II) content-and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications.
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