Journal
CURRENT STEM CELL RESEARCH & THERAPY
Volume 14, Issue 6, Pages 460-465Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1574888X14666190214162453
Keywords
Endothelial colony forming cells (ECFCs); neovascularization; tissue engineering; tumor angiogenesis; vascular homeostasis; peripheral blood
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Funding
- National Natural Science Foundation of China [2016YFC1000405, 2018YFC1002900]
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Endothelial progenitor cells (EPCs) are implicated in multiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs' characteristics, classification and origins, a summary of the progress in preclinical studies with regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-ECFCs) for ischemia repair, tissue engineering and tumor, and highlight the necessity to select high proliferative CB-ECFCs and to optimize their recovery and expansion conditions.
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