Journal
CURRENT OPINION IN VIROLOGY
Volume 34, Issue -, Pages 117-129Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2019.01.004
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Funding
- EMBO Long-term Fellowship [EMBO ALTF 963-2014]
- VENI from the Netherlands Organization for Scientific Research (NWO)
- National Institutes of Health [R01 AI114730]
- Kwang Hua Educational Foundation
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Attachment of viruses to cell-surface receptors is the initial step in infection. Many mammalian viruses have evolved to recognize receptors that are glycans on cell-surface glycoproteins or glycolipids. Although glycans are a ubiquitous component of mammalian cells, the types of terminal structures expressed vary among different cell-types and tissues, and even between comparable cells and tissues from different species, frequently leading to specific tissue and species tropisms as a direct consequence of glycan receptor recognition. Covering the majority of known virus families, this review provides an overview of mammalian viruses that use glycans as receptors, and their roles in determining in host recognition and tropism.
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