Journal
CURRENT OPINION IN VIROLOGY
Volume 34, Issue -, Pages 10-17Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2018.11.006
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Funding
- NIAID NIH HHS [R01 AI074667, R01 AI050611] Funding Source: Medline
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Hepatitis E virus (HEV) infects both humans and other animal species. Recently, we have seen a steady increase in autochthonous cases of human HEV infection in certain areas especially in Europe, and large outbreaks in several African countries among the displaced population. This mini-review critically analyzes potential host, environmental, and viral factors that may be associated with the emergence of hepatitis E in humans. The existence of numerous HEV reservoir animals such as pig, deer and rabbit results in human exposure to infected animals via direct contact or through animal meat consumption. Contamination of drinking, irrigation and coastal water by animal and human wastes lead to emergence of endemic cases in industrialized countries and outbreaks in displaced communities especially in war-torn countries.
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