Journal
CELL REPORTS
Volume 26, Issue 7, Pages 1869-+Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2019.01.066
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Funding
- National Key R&D Program of China [2017YFA0105801]
- NIH [R01 AR059103, R61 AR073 409]
- Zhujiang Innovative and Entrepreneurial Talent Team Award of Guangdong Province [2016 ZT 06S 252]
- National Natural Science Foundation of China [30972951, 81671611]
- Natural Science Foundation of Guangdong Province [2014A030308005]
- Department of Science and Technology in Guangzhou City
- Department of Science and Technology in Guangdong Province
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High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor beta (TGF-beta)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities and differences with tTreg. Here, we demonstrate that iTregs are completely stable and fully functional under high salt conditions. High salt does not influence the development, differentiation, and functional activities of iTreg but affects Foxp3 stability and function of tTreg in vitro and in vivo. In addition, high salt does not significantly change the transcription profiles of the iTreg signature or pro-inflammatory genes. Therefore, we conclude that iTreg, unlike tTreg, are stable and functional in the presence of high salt. Our findings provide additional evidence that iTreg may have different biological features from tTreg and suggest a greater potential for clinical utility in patients with autoimmune diseases, in which the complicated role of environmental factors, including diet, must be considered.
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