Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 32, Pages 9437-9440Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201603899
Keywords
electrochemistry; green chemistry; heterocycles; N-N coupling; pyrazolidin-3,5-diones
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Funding
- DFG by the Excellence Initiative by the Graduate School Materials Science in Mainz [GSC 266]
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Pyrazolidin-3,5-diones are important motifs in heterocyclic chemistry and are of high interest for pharmaceutical applications. In classic organic synthesis, the hydrazinic moiety is installed through condensation using the corresponding hydrazine building blocks. However, most N,N'-diaryl hydrazines are toxic and require upstream preparation owing to their low commercial availability. We present an alternative and sustainable synthetic approach to pyrazolidin-3,5-diones that employs readily accessible dianilides as precursors, which are anodically converted to furnish the N-N bond. The electroconversion is conducted in a simple undivided cell under constant-current conditions.
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