Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 18, Pages 5483-5487Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201511733
Keywords
gold nanoparticles; nanoparticle uptake; physicochemical properties; polyethylene glycol; toxicity
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Funding
- European Commission (project FutureNanoNeeds)
- MINECO [MAT2013-48169-R]
- Alexander von Humboldt Foundation
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A homologous nanoparticle library was synthesized in which gold nanoparticles were coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the thickness of the shell of polyethylene glycol, was varied. Basic physicochemical parameters of this two-dimensional nanoparticle library, such as size, -potential, hydrophilicity, elasticity, and catalytic activity ,were determined. Cell uptake of selected nanoparticles with equal size yet varying thickness of the polymer shell and their effect on basic structural and functional cell parameters was determined. Data indicates that thinner, more hydrophilic coatings, combined with the partial functionalization with quaternary ammonium cations, result in a more efficient uptake, which relates to significant effects on structural and functional cell parameters.
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