Journal
ADVANCED HEALTHCARE MATERIALS
Volume 8, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201801217
Keywords
cardiac patches; decellularized; extracellular matrices; injectable hydrogels
Funding
- Cell and Tissue Engineering NIH Biotechnology Training Grant [T32 GM-008433]
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Decellularized extracellular matrix (dECM) is a promising biomaterial for repairing cardiovascular tissue, as dECM most effectively captures the complex array of proteins, glycosaminoglycans, proteoglycans, and many other matrix components that are found in native tissue, providing ideal cues for regeneration and repair of damaged myocardium. dECM can be used in a variety of forms, such as solid scaffolds that maintain native matrix structure, or as soluble materials that can form injectable hydrogels for tissue repair. dECM has found recent success in many regeneration and repair therapies, such as for musculoskeletal, neural, and liver tissues. This review focuses on dECM in the context of cardiovascular applications, with variations in tissue and species sourcing, and specifically discusses advances in solid and soluble dECM development, in vitro studies, in vivo implementation, and clinical translation.
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