Journal
ADVANCED HEALTHCARE MATERIALS
Volume 8, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201801324
Keywords
bioimaging; dual-modal; scintillator; single irradiation
Funding
- National Natural Science Foundation of China [21871139, 61505077, 21501089]
- Natural Science Foundation of Jiangsu Province, China [BK20150936, BK20150939]
- National Key Research and Development Program of China [2017YFA0104302]
- National Natural Science Foundation of China for Key Project of International Cooperation [61420106012]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- CAS/SAFEA International Partnership Program for Creative Research Teams
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The rising demand for clinical diagnosis tools has led to extensive research on multimodal bioimaging systems. Unlike single-modal detection, multimodal imaging not only can provide both function and structure information but also can address the issue of sensitivity, depth, and cost. Despite enormous efforts, conventional step-by-step procedures for obtaining multimodal imaging pose a significant constraint on their practical applications. In this work, X-rays as highly penetrating radiation is proposed as a single-irradiation resource, while lanthanide-based nanostructure scintillators are employed as the single contrast agent to attenuate and convert X-rays, achieving computer tomography (CT) and optical dual-modal imaging at the same time. In other words, CT and optical dual-modal imaging are simultaneously produced via single radiation combined with single contrast agent. The function and structure information of targeted tumors in a mouse model can be clearly provided with large penetration and high sensitivity, indicating that this strategy is a simple but promising route for multimodal imaging of molecular disease and preclinical applications.
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