Journal
WORLD NEUROSURGERY
Volume 122, Issue -, Pages 417-423Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.wneu.2018.11.011
Keywords
Long-term survival; Pituitary carcinoma; Pituitary neoplasm transformation
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Funding
- University of Alabama Department of Neurosurgery
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BACKGROUND: Pituitary carcinomas are rare and aggressive neoplasms that despite current treatment regimens continue to have a poor prognosis. Adrenocorticotrophic hormone pituitary tumors have been shown to alter their clinical manifestations with conversion to Cushing disease and silent types. CASE DESCRIPTION: The purpose of this paper is to present the first documented case of an adrenocorticotrophic hormone-secreting pituitary adenoma with Cushing disease that differentiated into a silent corticotroph pituitary carcinoma with metastases to distant sites in the central nervous system. CONCLUSIONS: This patient was later treated with radiotherapy, temozolo-mide, and bevacizumab, with 8 years of progression-free survival.
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