Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 28, Pages 7988-7992Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201602219
Keywords
asymmetric hydrogenation; enamides; iridium; ligand design; P ligands
Categories
Funding
- Spanish MINECO [CTQ2014-56361-P]
- IRB Barcelona
- Generalitat de Catalunya
- MINECO
- Severo Ochoa Award of Excellence from MINECO (Government of Spain)
Ask authors/readers for more resources
The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from alpha-and beta-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H-2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and ethyl acetate, with no loss of selectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available