Journal
THORACIC CANCER
Volume 10, Issue 4, Pages 909-917Publisher
WILEY
DOI: 10.1111/1759-7714.13027
Keywords
FLOT1; lung adenocarcinoma; malignant behavior; signaling pathway
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Funding
- Natural Science Foundation of China [81372321]
- Six Talent Peaks Project of Jiangsu Province [2015-WSN-041, 2015-WSN-017]
- 333 Project of Jiangsu Province
- Nanjing City Key Clinical Department
- Jiangsu Province Geriatric Hospital Key Clinical Department
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BackgroundFLOT1 is a scaffolding protein of lipid rafts that is believed to be involved in numerous cellular processes. However, few studies have explored the function of FLOT1 in the development of lung adenocarcinoma (LUAD) and the underlying mechanisms of FLOT1 activity. MethodsFLOT1 knockdown and overexpression models were constructed via lentivirus. Cell growth, invasion, migration, and apoptosis were detected to evaluate the role of FLOT1 in LUAD development. Epithelial-mesenchymal transition (EMT) and cell cycle regulatory markers were then examined. Finally, the influence of FLOT1 on the Erk/Akt signaling pathway was investigated. ResultsFLOT1 promoted cell growth, invasion, and migration and inhibited cell apoptosis. In addition, FLOT1 induced EMT and modulated the cell cycle by activating the Erk/Akt signaling pathway. ConclusionThe findings indicate a significant role of FLOT1 in LUAD development. Targeting FLOT1 may be a potential therapeutic strategy for LUAD.
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