Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 49, Pages 15387-15391Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609337
Keywords
arylations; C-H activation; enantioselectivity; palladium; reaction mechanism
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Funding
- State Key Laboratory of Elemento-Organic Chemistry at Nankai University
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A new enantioselective palladium(II)-catalyzed benzylic C-H arylation reaction of amines is enabled by the bidentate picolinamide (PA) directing group. This reaction provides the first example of enantioselective benzylic -C-H arylations of alkyl amines, and proceeds with up to 97% ee. The 2,2-dihydroxy-1,1-binaphthyl (BINOL) phosphoric acid ligand, Cs2CO3, and solvent-free conditions are essential for high enantioselectivity. Mechanistic studies suggest that multiple BINOL ligands are involved in the stereodetermining C-H palladation step.
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