Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 23, Pages 6749-6752Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601930
Keywords
chemoselectivity; green chemistry; hydrodeiodination; radicals; transition-metal free synthesis
Categories
Funding
- WWU Munster
Ask authors/readers for more resources
A simple and efficient method for radical hydro-deiodination is reported. The novel approach uses electron catalysis. In situ generated Na-alcoholates are introduced as radical chain reducing reagents and reactions work with O-2 as cheap initiator. Hydrodeiodination works on aryl, alkenyl, alkynyl iodides and a tert-alkyl iodide also gets reduced applying the method. Albeit less general, the method is also applicable to the reduction of aryl bromides. The novel reagent is successfully used to conduct typical reductive radical cyclization reactions and mechanistic studies are reported.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available