Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 18, Pages 5555-5559Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601082
Keywords
C-H activation; fluorine; halogenation; heterocycles; palladium
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Funding
- Universite de Bourgogne (MESR PhD grant)
- Region Bourgogne (PARI II CDEA program)
- CNRS (3MIM-P4 program)
- Institut Universitaire de France IUF
- CNRS
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A general catalyzed direct C-H functionalization of s-tetrazines is reported. Under mild reaction conditions, N-directed ortho-C-H activation of tetrazines allows the introduction of various functional groups, thus forming carbon-heteroatom bonds: C-X (X=I, Br, Cl) and C-O. Based on this methodology, we developed electrophilic mono- and poly-ortho-fluorination of tetrazines. Microwave irradiation was optimized to afford fluorinated s-aryltetrazines, with satisfactory selectivity, within only ten minutes. This work provides an efficient and practical entry for further accessing highly substituted tetrazine derivatives (iodo, bromo, chloro, fluoro, and acetate precursors). It gives access to ortho-functionalized aryltetrazines which are difficult to obtain by classical Pinner-like syntheses.
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