An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2 Group to Molecules

An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF(2)PO(OEt)(2)) was designed. Under mild and metal-free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C-SCF2PO(OR)(2), N-SCF2PO(OR)(2), and S-SCF2PO(OR)(2) bonds. Finally, thanks to this new methodology, the synthesis of the non-stereoidal anti-inflammatory diflumidone was achieved.