Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 41, Pages 12637-12642Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201605745
Keywords
antiviral; cell permeability; cyclic peptides; HIV Rev; peptidomimetics
Categories
Funding
- NIA NIH HHS [R21 AG052813] Funding Source: Medline
Ask authors/readers for more resources
We present here an efficient alternative to N-methylation for the purpose of morphing protein-binding peptides into more serum-stable and cell-permeable compounds. This involves the incorporation of a cycloalanine (CyAla) into a peptide in a way that avoids difficult coupling steps. We demonstrate the utility of this chemistry in creating a cell-permeable derivative of a high-affinity HIV Rev protein-binding peptide.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available