Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 37, Pages 11106-11109Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201604677
Keywords
DNA; enzymes; membranes; nanopores; nanotechnology; polymersomes
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Funding
- Biotechnology and Biological Sciences Research Council [BB/M025373/1, BB/M012700/1, BB/N017331/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/N009282/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/M025373/1, BB/M012700/1, BB/N017331/1] Funding Source: Medline
- BBSRC [BB/M025373/1, BB/M012700/1, BB/N017331/1] Funding Source: UKRI
- EPSRC [EP/N009282/1] Funding Source: UKRI
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Chemistry plays a crucial role in creating synthetic analogues of biomacromolecular structures. Of particular scientific and technological interest are biomimetic vesicles that are inspired by natural membrane compartments and organelles but avoid their drawbacks, such as membrane instability and limited control over cargo transport across the boundaries. In this study, completely synthetic vesicles were developed from stable polymeric walls and easy-to-engineer membrane DNA nanopores. The hybrid nanocontainers feature selective permeability and permit the transport of organic molecules of 1.5nm size. Larger enzymes (ca. 5nm) can be encapsulated and retained within the vesicles yet remain catalytically active. The hybrid structures constitute a new type of enzymatic nanoreactor. The high tunability of the polymeric vesicles and DNA pores will be key in tailoring the nanocontainers for applications in drug delivery, bioimaging, biocatalysis, and cell mimicry.
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