Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 14, Pages 4500-4503Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201600112
Keywords
controlled radical polymerization; glucose oxidase; high-throughput screening
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Funding
- EPSRC [EP/K020641/1]
- EPSRC [EP/K020641/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K020641/1] Funding Source: researchfish
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The synthesis of well-defined polymers in a low-volume, combinatorial fashion has long been a goal in polymer chemistry. Here, we report the preparation of a wide range of highly controlled homo and block co-polymers by Enz-RAFT (enzyme-assisted reversible addition-fragmentation chain transfer) polymerization in microtiter plates in the open atmosphere. The addition of 1m glucose oxidase (GOx) to water/solvent mixtures enables polymerization reactions to proceed in extremely low volumes (40L) and low radical concentrations. This procedure provides excellent control and high conversions across a range of monomer families and molecular weights, thus avoiding the need to purify for screening applications. This simple technique enables combinatorial polymer synthesis in microtiter plates on the benchtop without the need of highly specialized synthesizers and at much lower volumes than is currently possible by any other technique.
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