Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 17, Pages 5225-5229Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601364
Keywords
bioinorganic chemistry; calcification; cell encapsulation; folate; tumor inhibition
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Funding
- Fundamental Research Funds for the Central Universities of China (ZJU President Program)
- National Natural Science Foundation of China [21571155, 21201150]
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Herein, we propose a drug-free approach to cancer therapy that involves cancer cell targeting calcification (CCTC). Several types of cancer cells, such as HeLa cells, characterized by folate receptor (FR) overexpression, can selectively adsorb folate (FA) molecules and then concentrate Ca2+ locally to induce specific cell calcification. The resultant calcium mineral encapsulates the cancer cells, inducing their death, and invivo assessments confirm that CCTC treatment can efficiently inhibit tumor growth and metastasis without damaging normal cells compared with conventional chemotherapy. Accordingly, CCTC remarkably improve the survival rate of tumor mice. Notably, both FA and calcium ions are essential ingredients in human metabolism, which means that CCTC is a successful drug-free method for tumor therapy. This achievement may further represent an alternative cancer therapy characterized by selective calcification-based substitution of sclerosis for tumor disease.
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