Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 24, Pages 6959-6963Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601914
Keywords
amide bonds; biaryls; cross-coupling; N-C activation; nickel
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Funding
- Rutgers University
- NSF-MRI [CHE-1229030]
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The first Ni-catalyzed Suzuki-Miyaura coupling of amides for the synthesis of widely occurring biaryl compounds through N-C amide bond activation is reported. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents on both coupling partners. The reaction constitutes the first example of the Ni-catalyzed generation of aryl electrophiles from bench-stable amides with potential applications for a broad range of organometallic reactions.
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