4.8 Article

Oxidative Intramolecular 1,2-Amino-Oxygenation of Alkynes under AuI/AuIII Catalysis: Discovery of a Pyridinium-Oxazole Dyad as an Ionic Fluorophore

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 3, Pages 757-761

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201609335

Keywords

cell imaging; cyclization; fluorescent probes; gold; synthetic methods

Funding

  1. Department of Science and Technology (DST), New Delhi [SB/S1/OC-17/2013, EMR/2014/001235]
  2. Council of Scientific and Industrial Research (CSIR), New Delhi [CSC0108, CSC0130]
  3. CSIR

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Oxidative intramolecular 1,2-amino-oxygenation reactions, combining gold(I)/gold(III) catalysis, is reported. The reaction provides efficient access to a structurally unique ionic pyridinium-oxazole dyad with tunable emission wavelengths. The application of these fluorophores as potential biomarkers has been investigated.

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